Sao Paulo have lost their previous two games in the top flight, while the visitors have picked up four points from their last two league matches.
The month of June started positively for Sao Paulo, who progressed to the quarter-finals of the Copa do Brasil after beating Sport Recife on penalties.
However, they were quickly stopped in their tracks by a 2-1 defeat to Gremio, bringing an end to their eight-game unbeaten league run.
Sao Paulo responded with a commanding 5-0 victory over Tolima in the Copa Sudamericana, but they were unable to produce that sort of dominant performance in their previous league fixture with Palmeiras, falling to a 2-0 home defeat.
The result ruined Sao Paulo’s 100% home record and leaves them in eighth place with 10 points to their name from 15 matches.
Dorival Junior’s side will be confident of bouncing back against Atletico Paranaense, having avoided defeat in their last three home meetings with Wednesday’s opponents.
Athletico Paranaense began the month with a penalty-shootout defeat to Botafago in the last 16 of the Copa do Brasil, but immediately avenged their cup exit with a 1-0 win over the Botafago in the league.
After edging out Libertad via a 1-0 scoreline in the Copa Libertadores, the Furacao looked set to claim three consecutive victories in all competitions when they took a two-goal lead in their most recent fixture against America MG.
However, strikes from Vitor Roque and Christian were cancelled by Wellington Paulista and Danilo Avelar to deny Athletico Paranaense their second away win of the Brasileiro season.
Despite having to settle for a 2-2 draw, Athletico Paranaense will head into the midweek contest in seventh place and one point better off than Sao Paulo.
Although they are searching for their first away win over Sao Paulo since November 2019, they may be able to draw inspiration from the 1-0 win that they picked up in their most home recent meeting against Wednesday’s opponents in July 2022.
Sao Paulo Brasileiro form:
Sao Paulo form (all competitions):
Athletico Paranaense Brasileiro form:
Athletico Paranaense form (all competitions):
We say: Sao Paulo 2-1 Athletico Paranaense
Sao Paulo have won four of their five home league games this season, and we think that they will make full use of home advantage when they face an Athletico Paranaense side who have lost three of their opening five away matches in the Brasileiro.