The hosts will be looking for a second consecutive league victory to move them closer to safety, while Genoa will be hoping to break a six-game winless run which has seen them drop to just six points above the relegation zone.
Parma recorded a crucial victory last time out, picking up a surprise 2-0 win over sixth-placed Roma thanks to goals from Valentin Mihaila and Hernani.
That put an end to a run of 17 league games without a victory for Roberto D’Aversa’s side, which saw them drop into the relegation zone.
However, they now sit just four points adrift of safety, with a win in this game moving them to within a point of 17th-placed Torino.
Despite their lowly league position, D’Aversa’s men have shown signs of improvement recently, having lost just one of their last five Serie A outings.
Before the victory over Roma, the Ducali looked set to record an impressive away victory over Fiorentina, when Mihaila scored late to put his side 3-2 ahead after they trailed 2-0.
However, they suffered late heartbreak as centre-back Simone Iacoponi turned the ball into his own net in the fourth minute of added time, with the game finishing 3-3.
D’Aversa will be hoping that his side can continue that steady improvement in this game, as they look to defy the odds and claw themselves closer to safety.
That will be no easy task though, as they host a Genoa side who will be desperate for a win of their own in their bid to remain comfortably ahead of the bottom three.
The visitors come into this game without a win in their last six league games, a run which has seen them drop uncomfortably close to the drop zone.
Davide Ballardini’s men picked up a point last time out with a 1-1 draw away at Udinese, as Goran Pandev’s early opener was cancelled out by a Rodrigo De Paul penalty for the hosts.
Il Grifone now sit just six points ahead of Cagliari in the relegation zone, while a defeat for Ballardini’s side on Friday would see the gap between themselves and Parma reduced to just three points.
As a result, they will be searching for a much-needed win on the road, as they look to increase their distance from the bottom three.