Champions Chelsea begin the defence of their Barclays Premier League title at home to newly-promoted West Bromwich Albion managed by former Stamford Bridge favourite Roberto di Matteo.
Runners-up Manchester United also kick off against a promoted side as Newcastle United visit Old Trafford.
It is a re-run of the opening-day fixture in 2008/09 when the sides drew 1-1. At the end of the campaign, the Magpies were relegated and United went on to win the title.
The other new-boys Blackpool’s first ever Barclays Premier League fixture will be a local derby at home to Wigan Athletic. They then go to Arsenal before hosting Fulham.
But perhaps the pick of the opening day fixtures is a re-run of last season’s intriguing battle for a Champions League place.
After pipping Manchester City for fourth spot, Tottenham Hotspur begin at home to Roberto Mancini’s side while Liverpool host Arsenal who finished third last season.
It promises to be a mouth-watering start to the new campaign. Aston Villa who finished sixth begin at home to West Ham United who just avoided relegation and who will be playing their first match under new manager Avram Grant.
Local rivals Wolverhampton Wanderers and Stoke City meet at Molineux and Sunderland manager Steve Bruce faces his old club Birmingham City at the Stadium of Light.
Everton make the short journey to Blackburn Rovers while Bolton Wanderers are at home to Fulham.
Fans will be keen to see the key matches between the teams who finished in the top four last season, although fixture dates are still subject to change.
The first of these is currently scheduled for 2nd October when champions Chelsea host Arsenal.
The first meeting between last season’s top two comes at Stamford Bridge on 18th December and the sides do battle again a fortnight before the end of the season as Chelsea visit Old Trafford on 7th May.
There is a festive feast on Boxing Day when Arsenal host Chelsea and the first real heavyweight encounter comes on 18th September when Manchester United meet Liverpool at Old Trafford.
The season boils up to an intriguing finale with champions Chelsea finishing at Everton while title hopefuls United host Blackpool.
Arsenal are at Fulham, Liverpool go to Aston Villa and Manchester City visit Bolton while Spurs finish at home to Birmingham. Newly-promoted sides Newcastle and West Brom face each other at St James’ Park.
All dates and kick-off times have still to be confirmed and the fixtures are still subject to change.
Aston Villa v West Ham
Blackburn v Everton
Blackpool v Wigan
Bolton v Fulham
Chelsea v West Brom
Liverpool v Arsenal
Man Utd v Newcastle
Sunderland v Birmingham
Tottenham v Man City
Wolverhampton v Stoke
Arsenal v Chelsea
Aston Villa v Tottenham
Blackburn v Stoke
Blackpool v Liverpool
Bolton v West Brom
Everton v Birmingham
Fulham v West Ham
Man Utd v Sunderland
Newcastle v Man City
Wolverhampton v Wigan
Aston Villa v Liverpool
Bolton v Man City
Everton v Chelsea
Fulham v Arsenal
Man Utd v Blackpool
Newcastle v West Brom
Stoke v Wigan
Tottenham v Birmingham
West Ham v Sunderland
Wolverhampton v Blackburn
All fixtures are still provisional and subject to change.